Tissue Antigens. 1991 Sep;38(3):104-6.

HLA association of idiopathic Peyronie's disease: an indication of autoimmune phenomena in etiopathogenesis?

Rompel R, Weidner W, Mueller-Eckhardt G.

Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.

HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, A1 (pc less than 0.05) and DQw2 (pc less than 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.

Publication Types: Research Support, Non-U.S. Gov't

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