Cancer Genet Cytogenet. 1999 Jan 15;108(2):137-40.

Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease.

Dal Cin P, De Smet L, Sciot R, Van Damme B, Van den Berghe H.

Center for Human Genetics, University of Leuven, Belgium.

Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. Instead, recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells.

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